地西泮在口服後，迅速被身體吸收，藥效很快開始，以靜脈注射，藥效更快。地西泮經肝臟代謝，其代謝物經腎臟排泄，只有極少量的地西泮沒有被代謝便排泄。
It might bring about dizziness. Never generate or do just about anything that requires mental target until finally you understand how this medication influences you.
If you employ diazepam regularly though breastfeeding, You will find a likelihood it could pass into your breast milk and Create up in the child’s procedure and induce sleepiness or affect your child’s weight acquire.
Geriatric Use In aged patients, it is suggested which the dosage be limited to the smallest efficient quantity to preclude the development of ataxia or oversedation (two mg to 2.five mg a couple of times daily, at first to generally be enhanced gradually as required and tolerated).
The anticonvulsant properties of diazepam together with other benzodiazepines could possibly be partially or completely due to binding to voltage-dependent sodium channels rather then GABAA receptors.
If you're thinking that you may have overdosed on diazepam, Call your unexpected emergency companies immediately or the closest poison Management Heart. Overdoses of benzodiazepines (including diazepam) tend to be manifested by indications ranging from drowsiness, difficulty respiration to coma.
薬の処方ハンドブック（羊土社） — 類似の処方集に「今日の処方」（南江堂）などがある。
To assure the Harmless and efficient usage of benzodiazepines, sufferers need to be educated that, given that benzodiazepines may perhaps deliver psychological and Actual physical dependence, it is recommended which they consult with their health practitioner prior to possibly escalating the dose or abruptly discontinuing this drug.
Diazepam is very lipid-soluble and is widely dispersed throughout the human body soon after administration. It very easily crosses each the blood–Mind barrier along with the placenta, and is also excreted into breast milk.
A transient syndrome whereby the signs and symptoms that led to treatment with diazepam recur within an Increased sort. This will likely take place on discontinuation of cure. It might be accompanied by other reactions which include mood improvements, anxiety, and restlessness.
Psychiatric and paradoxical reactions are recognized to manifest when using benzodiazepines (see ADVERSE REACTIONS). Should this occur, use in the drug really should be discontinued. These reactions usually tend to arise more info in little ones as well as the elderly.
ジアゼパムを過量に摂取した人は、傾眠の傾向、意識の昏迷、昏睡、腱反射の減弱といった徴候を示す。ジアゼパムの過量摂取は救急医療的な状態であり、救急医療関係者による迅速な発見が必要である。この場合の拮抗薬はフルマゼニル（アネキセート）である。ジアゼパムの作用が消失するには数日かかり、フルマゼニルは短期間作用型の薬剤であるためフルマゼニルの連続投与が必要になることがある。必要に応じて、気管挿管と心肺機能の管理を行うべきである。人間の、経口摂取でのジアゼパムの致死量は500mgないしそれ以上と見積もられている。300mgを経口摂取した症例でも、睡眠時間の延長と連続した傾眠傾向だけで、重篤な合併症もなく回復してしまったこともある。ただし、ジアゼパムとアルコール、その他の中枢神経抑制薬の併用では場合により致命的となる。
小児の薬の選び方・使い方（南山堂） — 小児科領域の処方に関する概説書。
A lessen dose is suggested for patients with Continual respiratory insufficiency, because of the potential risk of respiratory depression.